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Under a Creative Commons license open access Keywords Bcl-2 protein pore Mitochondrial membrane Cytochrome c release Apoptosis 1. Introduction Bcl-2 family proteins are evolutionarily conserved molecules that play a pivotal role in control of apoptotic protein release from mitochondria.1, 2, 3, 4, 5 They share Bcl-2 homology (BH) domains that are defined by sequence and structural homology and important for their interactions and functions.
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