DW Eyles on Muck Rack

DW Eyles

As seen in: Nature
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“Intranasal clozapine sol-gel formulation induces an antipsychotic effect at a fraction of a comparable oral therapeutic dose”

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By S. Alexander, P. C. Pandey, D. E. Siskind, M. Ali, X. -J. Cui, DW Eyles, HS Parekh, M. Langguth, R. Lohman
| Nature
Abstract Clozapine is arguably the most effective antipsychotic in the treatment of schizophrenia. However, clozapine comes with a substantial and even sometimes lethal side-effect burden. The vast majority of side-effects are peripherally induced, requiring additional pharmacotherapy. An approach to diminishing such debilitating side-effects would be to minimize drug access to the periphery through consideration of other dosage forms and routes of administration.
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