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Dylan Ehrbar

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Articles

Serum antibody profiling identifies vaccine-induced correlates of protection against aerosolized ricin toxin in rhesus macaques - npj Vaccines

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By Chad J Roy, Dylan Ehrbar
| Nature Verified
Abstract Inhalation of the biothreat agent, ricin toxin (RT), provokes a localized inflammatory response associated with pulmonary congestion, edema, neutrophil infiltration, and severe acute respiratory distress. The extreme toxicity of RT is the result of the toxin’s B chain (RTB) promoting rapid uptake into alveolar macrophages and lung epithelial cells, coupled with the A chain’s (RTA) potent ribosome-inactivating properties.
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Passive immunization with an extended half-life monoclonal antibody protects Rhesus macaques against aerosolized ricin toxin

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By Dylan Ehrbar, Chad J Roy, Greta Van Slyke, Nicholas J. Mantis
| Nature Verified
Abstract Inhalation of ricin toxin (RT), a Category B biothreat agent, provokes an acute respiratory distress syndrome marked by pro-inflammatory cytokine and chemokine production, neutrophilic exudate, and pulmonary edema. The severity of RT exposure is attributed to the tropism of the toxin’s B subunit (RTB) for alveolar macrophages and airway epithelial cells, coupled with the extraordinarily potent ribosome-inactivating properties of the toxin’s enzymatic subunit (RTA).
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Humanized Monoclonal Antibody Rescues Rhesus macaques from Aerosolized Ricin Toxin Exposure

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By Chad J Roy, Dylan Ehrbar, Natasha Bohorova, Ognian Bohorov
| BioRxiv
Humanized Monoclonal Antibody Rescues Rhesus macaques from Aerosolized Ricin Toxin Exposure Chad J Roy, Dylan Ehrbar, Natasha Bohorova, Ognian Bohorov, Do Kim, Michael Pauley, Kevin Whaley, Yinghui Rong, Fernando J Torres-Velez, Ellen Vitetta, Peter J Didier, Lara Doyle-Meyers, Larry Zeitlin, Nicholas Mantis bioRxiv 407817; doi: https://doi.org/10.1101/407817
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