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Dylan Noone

As seen in: Nature, BioRxiv
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Articles by Dylan Noone

Internalized components of membrane attack complexes disrupt proteostasis and acquire alarmin-like properties

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By Guiyu Song, Zihan Ma, Matthew Fan, Liying He, Yulong Lan, Weihao Li, Zhengtao Jiang, Quan Jiang, Dylan Noone, Andrea Nans, Kamal L. Nahas, Mahsa Nouri Barkestani, Shaoxun Wang, Qianxun Wang, Pengwei Ren, Haitian Zhou, Justin Johnson, Clancy Mullan, Xiangyu Gong, Doryen Bubeck, Gilbert Moeckel, Michael Mak, George Tellides, Dan Jane-Wit, Jolin Cheng, Yinuo Zang
| Nature Verified
Abstract Immune effects of membrane attack complexes (MAC) have been widely attributed to their abilities to cause cell death. Here, we show that the MAC component, C9, forms non-cytolytic aggregates with pro-inflammatory effects. Intracellular aggregates of C9 are detected within inflamed tissues of patients in association with endothelial cell (EC) activation but not increased cell death.
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Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein

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By Marjolein M.E. Isendoorn, Dylan Noone, Sebastiaan Hamers, Mariska Keizer
| BioRxiv
Abstract Human C-reactive protein (CRP) is a pentameric complex involved in defence against pathogens and regulation of autoimmunity. CRP is also a therapeutic target, with both administration and depletion of serum CRP being pursued as a possible treatment for autoimmune and cardiovascular diseases, among others. CRP binds to phosphocholine (PC) moieties on membranes in order to activate the complement system via the C1 complex, but it is unknown how CRP, or any pentraxin, binds to C1.
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