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Yinuo Zang

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Articles

Internalized components of membrane attack complexes disrupt proteostasis and acquire alarmin-like properties

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By Guiyu Song, Zihan Ma, Matthew Fan, Liying He, Yulong Lan, Weihao Li, Zhengtao Jiang, Quan Jiang, Dylan Noone, Andrea Nans, Kamal L. Nahas, Mahsa Nouri Barkestani, Shaoxun Wang, Qianxun Wang, Pengwei Ren, Haitian Zhou, Justin Johnson, Clancy Mullan, Xiangyu Gong, Doryen Bubeck, Gilbert Moeckel, Michael Mak, George Tellides, Dan Jane-Wit, Jolin Cheng, Yinuo Zang
| Nature Verified
Abstract Immune effects of membrane attack complexes (MAC) have been widely attributed to their abilities to cause cell death. Here, we show that the MAC component, C9, forms non-cytolytic aggregates with pro-inflammatory effects. Intracellular aggregates of C9 are detected within inflamed tissues of patients in association with endothelial cell (EC) activation but not increased cell death.
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