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Articles

Plaque-dependent morphological and electrophysiological heterogeneity of microglia in an Alzheimer's disease mouse model

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By Jan Niklas, DZNE Bonn Germany, Research Bonn Germany
| Color Research & Application Verified
Microglia, the central nervous system resident innate immune cells, cluster around A? plaques in Alzheimer's disease (AD). The activation phenotype of these plaque-associated microglial cells, and their differences to microglia distant to A? plaques, are incompletely understood. We used novel three-dimensional cell analysis software to comprehensively analyze the morphological properties of microglia in the TgCRND8 mouse model of AD in spatial relation to A? plaques.
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