E. Baraldi

CASE HISTORY A previously healthy 3-yr-old male was evaluated for fever and abdominal pain, and a chest radiograph was performed (fig. 1⇓). A detailed history was collected and the parents reported the child having a “distended abdomen” from a few months old. They had the impression he was a calm child, less inclined to run and play than his peers.

Abstract There is poor agreement on definitions of different phenotypes of preschool wheezing disorders. The present Task Force proposes to use the terms episodic (viral) wheeze to describe children who wheeze intermittently and are well between episodes, and multiple-trigger wheeze for children who wheeze both during and outside discrete episodes. Investigations are only needed when in doubt about the diagnosis.

Isocyanate-induced asthmatic reactions are associated with delayed increase in fractional exhaled nitric oxide measured at expiratory flow of 50 mL/s (FeNO50), a biomarker of airway inflammation. The time course of FeNO increase is compatible with the activation of NO synthase, but the origin of NO production in the lung is undetermined.