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MEMBRANE VESICLES DERIVED FROM BORDETELLA BRONCHISEPTICA: ACTIVE CONSTITUENT OF A NEW VACCINE AGAINST INFECTIONS CAUSED BY THIS PATHOGEN
Bordetella bronchiseptica, a Gram-negative bacterium, causes chronic respiratory-tract infections in a wide variety of mammalian hosts—humans included, albeit rarely. We recently designed B. pertussis and B. parapertussis experimental vaccines based on outer-membrane vesicles derived from each pathogen and obtained protection against the respective infections in mice. Here, we demonstrate that outer-membrane vesicles derived from virulent-phase B.
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