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E. Barton Prideaux on Muck Rack

E. Barton Prideaux

As seen in: Nature, Wiley Online Library, BioRxiv
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Articles

Epigenetic trajectory predicts development of clinical rheumatoid arthritis in ACPA+ individuals: Targeting Immune Responses for Prevention of Rheumatoid Arthritis (TIP-RA)

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By E. Barton Prideaux, David Boyle, Eunice Choi, Jane H Buckner
| BioRxiv
Abstract Objective The presence of autoantibodies to citrullinated protein antigens (ACPAs) in the absence of clinically-apparent inflammatory arthritis (IA) identifies individuals at-risk for developing future clinical rheumatoid arthritis (RA). However, it is unclear why some ACPA+ individuals convert to clinical RA while others do not.
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Laser Capture Microscopy RNA Sequencing for Topological Mapping of Synovial Pathology During Rheumatoid Arthritis

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By Benjamin Van Espen, E. Barton Prideaux, Andrew Wilson, Sho Sendo
| Wiley Online Library Verified
Objective Rheumatoid arthritis (RA) is an autoimmune disease in which the joint lining or synovium becomes highly inflamed and majorly contributes to disease progression. Understanding pathogenic processes in RA synovium is critical for identifying therapeutic targets. We performed laser capture microscopy (LCM) followed by RNA sequencing (LCM-RNAseq) to study regional transcriptomes throughout RA synovium.
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Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis - Nature Communications

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By Eddie A James, Radhika Iyer, Amin Zia, Julia Adamska, R. Camille Brewer, Yuko Okamoto, Ryan Peterson, Wei Qing Wang, Jane H Buckner, Gary S. Firestein, E. Barton Prideaux, Christopher C. Striebich
| Nature Verified
Abstract Molecular markers of autoimmunity, such as antibodies to citrullinated protein antigens (ACPA), are detectable prior to inflammatory arthritis (IA) in rheumatoid arthritis (RA) and may define a state that is ‘at-risk’ for future RA. Here we present a cross-sectional comparative analysis among three groups that include ACPA positive individuals without IA (At-Risk), ACPA negative individuals and individuals with early, ACPA positive clinical RA (Early RA).
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