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The evidence for Internet‐delivered pain management programs for chronic pain is growing, but there is little empirical understanding of how they effect change. Understanding mechanisms of clinical response to these programs could inform their effective development and delivery.
Bioresorbable vascular scaffolds were developed to overcome the shortcomings of drug-eluting stents in percutaneous coronary intervention (PCI). We performed an investigator-initiated, randomized trial to compare an everolimus-eluting bioresorbable scaffold with an everolimus-eluting metallic stent in the context of routine clinical practice. We randomly assigned 1845 patients undergoing PCI to receive either a bioresorbable vascular scaffold (924 patients) or a metallic stent (921 patients).
The bioresorbable vascular scaffold was approved by the Food and Drug Administration (FDA) and obtained a Conformité Européenne mark in 2010, which indicates market approval throughout the European Union. Although this device has gained acceptance in ordinary interventional practice, data from adequately powered, randomized studies addressing safety and efficacy are lacking in this context.
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