The New England Journal of Medicine

Are you a member of an institution such as a university or hospital?Learn more about Institutional Access Notes This article was published on July 4, 2026, at NEJM.org. Disclosure forms provided by the authors are available at NEJM.org. Supplementary Material Disclosure Forms (nejmp2602489_disclosures.pdf)

Are you a member of an institution such as a university or hospital?Learn more about Institutional Access Notes This article was published on July 4, 2026, at NEJM.org. Disclosure forms provided by the authors are available at NEJM.org. Supplementary Material Disclosure Forms (nejmp2604122_disclosures.pdf)

Are you a member of an institution such as a university or hospital?Learn more about Institutional Access Notes This article was published on July 4, 2026, at NEJM.org. Disclosure forms provided by the authors are available at NEJM.org. Supplementary Material Disclosure Forms (nejmp2603593_disclosures.pdf)

Published July 4, 2026 DOI: 10.1056/NEJMicm2603440 For permission requests, please contact NEJM Reprints at reprints@nejm.org Are you a member of an institution such as a university or hospital?Learn more about Institutional Access Notes This article was published on July 4, 2026, at NEJM.org.

Are you a member of an institution such as a university or hospital?Learn more about Institutional Access Notes This article was published on July 4, 2026, at NEJM.org. Disclosure forms provided by the author are available at NEJM.org. Supplementary Material Disclosure Forms (nejmp2517154_disclosures.pdf)

This feature about treatment of appendicitis offers a case vignette accompanied by two essays, one recommending operative management and the other supporting a nonoperative approach.

Published July 1, 2026 DOI: 10.1056/NEJMp2607819 For permission requests, please contact NEJM Reprints at reprints@nejm.org Fifty years after the first recognized Ebola outbreaks in central Africa, the ongoing Bundibugyo virus disease outbreak in the Democratic Republic of Congo (DRC) and Uganda serves as a stark reminder that critical gaps in epidemic preparedness remain.1,2 Immediate priorities include rapid detection, clinical care, infection prevention and control, contact tracing, safe...

Published July 1, 2026 N Engl J Med 2026;395:96-98 DOI: 10.1056/NEJMc2602051 For permission requests, please contact NEJM Reprints at reprints@nejm.org Are you a member of an institution such as a university or hospital?Learn more about Institutional Access Notes Philip M. Murphy can be contacted at pmm@nih.gov. Supported by the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health.

Published July 1, 2026 N Engl J Med 2026;395:101-103 DOI: 10.1056/NEJMc2606180 For permission requests, please contact NEJM Reprints at reprints@nejm.org Are you a member of an institution such as a university or hospital?Learn more about Institutional Access Information & Authors Published In History Published online: July 1, 2026 Published in issue: July 2, 2026 Metrics & Citations Export citation Select the format you want to export the citation of this publication.

Notes Yang Wang can be contacted at wang.yang@shsmu.edu.cn. Yang Wang, Xingjie Hao, and Zhonghua Yang contributed equally to this letter. Supported by a grant (81670469) from the National Natural Science Foundation of China, a grant (22ZR1451500) from the Natural Science Foundation of Shanghai, and a grant (17DZ2272000) from the Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition. Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.