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E. L. Barnes on Muck Rack

E. L. Barnes

As seen in: Color Research & Application
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Articles

The benefit of combination therapy depends on disease phenotype and duration in Crohn's disease

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By A. N. Ananthakrishnan, A. Sakuraba, E. L. Barnes, J. Pekow, L. Raffals, M. D. Long, R. S. Sandler
| Color Research & Application Verified
Using a multicenter prospective cohort, we classified CD and UC patients as being on monotherapy with anti-TNF or on combination with an immunomodulator. The primary outcome was a composite of new IBD-related surgery, hospitalisations, penetrating complications, need for corticosteroids or new biological at 1 year. Multivariable regression models adjusted for potential confounders. We included 707 patients with CD (45% combination therapy) and 164 with UC (38% combination therapy).
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