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Ebtihal Kamal

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Articles

Integrating Artificial Intelligence and Bioinformatics Methods to Identify Disruptive STAT1 Variants Impacting Protein Stability and Function

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By Ebtihal Kamal, Lamis A. Kaddam, Mehad Ahmed, Abdulaziz Alabdulkarim
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Bioinformatics Analysis of Non-Coding UTR Variants in STAT1 Reveals Disruption of miRNA Binding, mRNA Stability, and Oncogenic Potential

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By Ebtihal Kamal, Mehad Ahmed
| biorxiv.org
Abstract Single nucleotide polymorphisms (SNPs) are associated with a wide range of disorders, including diverse cancer types. In the context of cancer, alterations within non-coding regions, specifically untranslated regions (UTRs), have proven substantially important. SNPs localized in the 3 prime UTRs of the STAT1 gene were assessed for their association with miRNAs using PolymiRTS, miRNASNP, and MicroSNIper.
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Integrating Bioinformatics and Artificial Intelligence Methods to identify disruptive STAT1 variants impacting Protein Stability and Function

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By Lamis A. Kaddam, Ebtihal Kamal, Mehad Ahmed, Abdulaziz Alabdulkarim
| biorxiv.org
Abstract The Signal Transducer and Activator of Transcription 1 (STAT1) gene is an essential component of the JAK-STAT signaling pathway. This pathway has a pivotal role in regulating different cellular processes, including immune responses, cell growth, and apoptosis. Mutations in the STAT1 gene contribute to various body pathologies [OMIM #600555], including immune system dysfunction. In the current study, we used eighteen online computational approaches.
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