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Articles by Eccles St
The history, development and current status of isotretinoin: a review article
Isotretinoin, a potent retinoid, is highly effective in the treatment of severe acne vulgaris. Its nearly 60-year history began with the Swiss pharmaceutical company La Roche in the 1960s, where it was initially studied for potential benefits in cancer treatment. This article delineates the historic trajectory of isotretinoin from early clinical trials in the 1970s and 1980s, highlighting its efficacy and safety profile, leading to FDA approval in 1982.
Cancer and older people. A research collection and commentary on the theme
Abstract Cancer disproportionately affects older adults, who account for the majority of diagnoses and deaths globally. However, research and clinical care often fail to adequately address their unique needs. This collection of studies in Age and Ageing highlights challenges and opportunities in geriatric oncology. The rising incidence of cancer in the older population, driven by demographic shifts and socioeconomic factors, underscores the need for targeted prevention and control strategies.
Associations between the gut microbiome, inflammation and cardiovascular profiles in people with HIV
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Inflammation and innate immune activation are associated with chronic HIV infection, despite effective treatment. Although gut microbiota alterations are linked to systemic inflammation, the relationships between the gut microbiome, inflammation and HIV remain unclear. The UPBEAT-CAD sub-study, examining cardiovascular disease (CVD) risk in HIV, enrolled participants matched on HIV status and traditional CVD risk factors.
By College Dublin, APC Microbiome Ireland, Alejandro Garcia Verified, Alejandro García Verified, Eccles St
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Oxford Academic
Verified
European consensus on patient contact shielding
Abstract Patient contact shielding has been in use for many years in radiology departments in order to reduce the effects and risks of ionising radiation on certain organs. New technologies in projection imaging and CT scanning such as digital receptors and automatic exposure control (AEC) systems have reduced doses and improved image consistency.
An examination of the effect of open versus paywalled access publication on the disseminative impact and citation count of publications in intensive care medicine and anesthesia
Measuring patient respect in the intensive care unit: Validation of the ICU-RESPECT instrument
Soluble glycoprotein VI, a specific marker of platelet activation is increased in the plasma of subjects with seropositive rheumatoid arthritis
Citation: Stack JR, Madigan A, Helbert L, Dunne E, Gardiner EE, Andrews RK, et al. (2017) Soluble glycoprotein VI, a specific marker of platelet activation is increased in the plasma of subjects with seropositive rheumatoid arthritis. PLoS ONE12(11): e0188027. https://doi.org/10.1371/journal.pone.0188027 Copyright: © 2017 Stack et al.
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