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Cancer-associated fibroblasts produce Netrin-1 to control cancer cell plasticity

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By Pei-Ju Sung, Nicolas Rama, Jeromine Imbach, Echappement tumoral
| cancerres.aacrjournals.org
Research Article Pei-Ju Sung, Nicolas Rama, Jeromine Imbach, Stephany Fiore, Benjamin Ducarouge, David Neves, Huei-Wen Chen, David Bernard, Pan-Chyr Yang, Agnès Bernet, Stephane Depil and Patrick Mehlen DOI: 10.1158/0008-5472.CAN-18-2952 Abstract Netrin-1 is upregulated in a large fraction of human neoplasms. In multiple animal models, interference with netrin-1 is associated with inhibition of tumor growth and metastasis.
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