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Edeltraud van Gumpel on Muck Rack

Edeltraud van Gumpel

As seen in: Cell Chemical Biology
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Articles

Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system

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By Raphael Gries, Jason Chhen, Edeltraud van Gumpel, Sebastian Theobald
| Cell Chemical Biology Verified
Global Tuberculosis Report. 2022 Kaufmann S.H.E. Lange C. Rao M. Balaji K.N. Lotze M. Schito M. Zumla A.I. Maeurer M. Progress in tuberculosis vaccine development and host-directed therapies--a state of the art review. Lancet Respir. Med. 2014; 2: 301-320 Advancing host-directed therapy for tuberculosis. Nat. Rev. Immunol. 2015; 15: 255-263 Gries R. Sala C. Rybniker J. Host-Directed Therapies and Anti-Virulence Compounds to Address Anti-Microbial Resistant Tuberculosis Infection. Applied Sciences-Basel.
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Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system

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By Raphael Gries, Jason Chhen, Edeltraud van Gumpel, Sebastian Theobald
| Cell Chemical Biology Verified
Highlights • 1,3,4-oxadiazoles limit intracellular growth of Mycobacterium tuberculosis • These compounds inhibit the mycobacterial ESX-1 secretion system • Some analogs have a dual mechanism and strongly improve ethionamide activity Summary Drug-resistant Mycobacterium tuberculosis (Mtb) remains a major public health concern requiring complementary approaches to standard anti-tuberculous regimens.
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Extremely Low Hit Rate in a Diverse Chemical Drug Screen Targeting Mycobacterium abscessus

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By Sandra J. Winter, Georg Plum, Jakob J. Malin, Edeltraud van Gumpel
| asm.org
Letter to the Editor Jakob J. Malin, Sandra Winter, Edeltraud van Gumpel, Georg Plum, Jan Rybniker DOI: 10.1128/AAC.01008-19 Log in using your username and password Username * Password * Forgot your user name or password? Log in through your institution You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password. If your organization uses OpenAthens, you can log in using your OpenAthens username and password.
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