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Edgar F. Kong on Muck Rack

Edgar F. Kong

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Host range, transmissibility and antigenicity of a pangolin coronavirus - Nature Microbiology

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By Yixuan Hou, Shiho Chiba, Sarah R. Leist, Rita M. Meganck, Alexandra Schafer, Rhianna E. Lee, Lily E. Adams, Edgar F. Kong, Melissa D. Mattocks, Scott Randell, Purushothama R. Tata, Peter Halfmann, Yoshihiro Kawaoka
| Nature Verified
Abstract The pathogenic and cross-species transmission potential of SARS-CoV-2-related coronaviruses (CoVs) remain poorly characterized. Here we recovered a wild-type pangolin (Pg) CoV GD strain including derivatives encoding reporter genes using reverse genetics. In primary human cells, PgCoV replicated efficiently but with reduced fitness and showed less efficient transmission via airborne route compared with SARS-CoV-2 in hamsters.
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