Edis Dzananovic on Muck Rack

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Impact of the structural integrity of the three-way junction of adenovirus VAI RNA on PKR inhibition

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By Edis Dzananovic, Grzegorz Chojnowski, Soumya Deo, Evan P. Booy
| PLOS
Highly structured RNA derived from viral genomes is a key cellular indicator of viral infection. In response, cells produce the interferon inducible RNA-dependent protein kinase (PKR) that, when bound to viral dsRNA, phosphorylates eukaryotic initiation factor 2? and attenuates viral protein translation. Adenovirus can evade this line of defence through transcription of a non-coding RNA, VA , an inhibitor of PKR.
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