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Edisa Pirani

As seen in: Frontiers, BioRxiv
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Articles

A Potent Nonapeptide Inhibitor for the CXCL12/HMGB1 heterocomplex: A Computational and Experimental Approach

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By Edisa Pirani, Andrea Cavalli, Gabriella Roda
| BioRxiv
Abstract Inflammation is a vital defense mechanism activated in response to injury or infection, which induces the release of cytokines and chemokines to promote tissue repair. However, persistent inflammation may result in the development of autoimmune diseases. During pathological conditions such as rheumatoid arthritis, HMGB1 is kept in its reduced isoform and can complex with CXCL12 enhancing cell migration and exacerbating the immune responses.
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The chemokine landscape: one system multiple shades

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By Diana Boraschi, Raffaella Bonecchi, Sofie Struyf, Edisa Pirani
| Frontiers
Valentina Cecchinato*, Veronica Martini*, Edisa Pirani, Elaheh Ghovehoud and Mariagrazia Uguccioni Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland Leukocyte trafficking is mainly governed by chemokines, chemotactic cytokines, which can be concomitantly produced in tissues during homeostatic conditions or inflammation.
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