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Articles by Edna Bode
Pseudotetraivprolides from Pseudomonas entomophila Provide Insights into the Biosynthesis of Detoxin/Rimosamide‐Like Anti‐Antibiotics
Introduction Bacteria carry biosynthesis gene clusters (BGCs) responsible for the production of bioactive natural products (NP). While we are able to speed up identification of NPs and their BGCs based on progress in mass spectrometry and bioinformatic tools like antiSMASH,[1, 2] we often do not understand well, how and for which ecological function they were evolved.
Pseudotetraivprolides from Pseudomonas entomophila Provide Insights into the Biosynthesis of Detoxin/Rimosamide‐Like Anti‐Antibiotics
Introduction Bacteria carry biosynthesis gene clusters (BGCs) responsible for the production of bioactive natural products (NP). While we are able to speed up identification of NPs and their BGCs based on progress in mass spectrometry and bioinformatic tools like antiSMASH,[1, 2] we often do not understand well, how and for which ecological function they were evolved.
Xenorhabdus and Photorhabdus Metabolites for Fungal Biocontrol and Application in Soybean Seed Protection
Photorhabdus and Xenorhabdus bacteria, members of the Morganellaceae family, are sources of novel natural products for the biocontrol of fungal pathogens in soybean production. This study demonstrated the inhibitory effects of metabolites from four Photorhabdus and Xenorhabdus strains (including a local isolate, X. szentirmaii PAM 25), against four key phytopathogenic fungi. Bacterial metabolite efficacy and fungal susceptibility varied. Xenorhabdus szentirmaii DSM 16338, X.
Identification, structure and function of the methyltransferase involved in the biosynthesis of the dithiolopyrrolone antibiotic xenorhabdin
Abstract Xenorhabdins (XRDs) are produced by Xenorhabdus species and are members of the dithiopyrrolone (DTP) class of natural products that have potent antibacterial, antifungal and anticancer activity. The amide moiety of their DTP core can be methylated or not to fine-tune the bioactivity properties. However, the enzyme responsible for the amide N-methylation remained elusive.
Publisher Correction: Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery
Correction to: Nature Communications https://doi.org/10.1038/s41467-021-23502-4, published online 28 May 2021. The original version of this Article omitted Bahar Behsaz and Edna Bode as equally contributing authors. The original version of this Article contained an error in the author affiliations. Pavel A. Pevzner was incorrectly associated with Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing
Cover Picture Gerd Geisslinger LOEWE-TBG, 60325 Frankfurt, Germany Fraunhofer Inst. for Mol. Biol. and Appl. Ecology, Branch for Translational Medicine and Pharmacology, 60596 Frankfurt, Germany Univ. Hospital Frankfurt, Clin. Pharmacol., 60590 Frankfurt, Germany Search for more papers by this author Helge B. Bode Corresponding Author E-mail address: h.bode@bio.uni-frankfurt.de http://orcid.org/0000-0001-6048-5909 Mol. Biotechnol., Univ.
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