Eduardo R Butelman

The impact of exposure to non-medical mu-opioid receptor (MOR) agonists in pregnant women, and its impact on offspring remains an area of great importance in mechanistic and clinical research. Gestational exposure to mu-opioid receptor agonists (e.g., synthetic opioids such as fentanyl, heroin or prescription opioids such as oxycodone), can potentially result in neurobehavioral changes in the offspring through several long-term developmental processes.

Abstract Recent years have shown increases in overdose (OD) mortality caused by polydrug exposure to synthetic opioids such as fentanyl and stimulants such as methamphetamine or cocaine. The goal of this study is to understand the recent trajectory in this polydrug OD mortality, especially as associated with decedents’ sex and age.

Abstract Measuring splicing and chromatin accessibility simultaneously in frozen tissues remains challenging. Here we combined single-cell isoform RNA sequencing and assay for transposase accessible chromatin (ScISOr–ATAC) to interrogate the correlation between these modalities in single cells in human and rhesus macaque frozen cortical tissue samples.