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Edukondalu Mullapudi on Muck Rack

Edukondalu Mullapudi

As seen in: Nature, Science Magazine, BioRxiv
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Articles

Architecture of an asymmetric short chain/long chain hybrid acyl‑CoA carboxylase from Mycobacterium smegmatis

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By Edukondalu Mullapudi, Matthias Wilmanns, Hai Minh Thai
| Nature Verified
Abstract Mycobacteria comprise an uneven number of genes coding for biotin carboxylase (BC) and acyl-CoA carboxyl transferase (CT) activities and an ε-subunit of unknown function. To unravel the composition of acyl-CoA carboxylase (ACCase) holoenzymes under native conditions, we pulled down endogenously expressed biotinylated proteins from Mycobacterium smegmatis.
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Master corepressor inactivation through multivalent SLiM-induced polymerization mediated by the oncogene suppressor RAI2

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By Nishit Goradia, Stefan Werner, Edukondalu Mullapudi, Sarah Greimeier
| BioRxiv
Abstract While the elucidation of regulatory mechanisms of folded proteins is facilitated due to their amenability to high-resolution structural characterization, investigation of these mechanisms in disordered proteins is more challenging due to their structural heterogeneity, which can be captured by a variety of biophysical approaches. Here, we used the transcriptional master corepressor CtBP, which binds the putative metastasis suppressor RAI2 through repetitive SLiMs, as a model system.
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Corepressor inactivation through tandem linear motif-induced polymerization

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By Stefan Werner, Edukondalu Mullapudi, Nishit Goradia, Sarah Greimeier
| BioRxiv
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