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Edward Arbe-Barnes on Muck Rack

Edward Arbe-Barnes

As seen in: Gut Journal, BioRxiv
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Articles

Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection

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By Anucha Preechanukul, Aljawharah Alrubayyi, Bo Sun, Edward Arbe-Barnes
| Gut Journal Verified
Library preparation and sequencing PBMCs with >96% viability were used.14 Library construction was performed using the 10x next GEM Chips Chromium single cell library 5’ construction kit (10x Genomics, Pleasanton) as per the manufacturer’s protocol. Briefly, a maximum of 3000 cells were combined with barcoded single cell VDJ gel beads, cells and partitioning oil onto Chromium Next GEM Chip K.
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Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments

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By Shivan Sivakumar, Piyush Sharma, Ashwin Jainarayanan, Edward Arbe-Barnes
| BioRxiv
Abstract Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. Understanding the multiple mechanisms by which the tumour evades immune control, and how these mechanisms may be disrupted is critical to developing targeted immunotherapies. Previous studies have shown that higher lymphocyte infiltration is associated with better survival, and here we investigated what mediates these differences.
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