From University of Utah School of Medicine, Salt Lake City, Utah; and Harvard Medical School, Boston, Massachusetts. CME Objective: To review current evidence for precautions, prophylaxis, treatment, diagnosis, and practice improvement of travel medicine. Disclosures: Dr. Ryan, ACP Contributing Author, reports grants from the Centers for Disease Control and Prevention during the conduct of the study. Drs. Leung and LaRocque, ACP Contributing Authors, have nothing to disclose.