Edward Watkins

Key Points Question Which specific components within internet-delivered cognitive behavioral therapy (CBT) for depression are active ingredients that reduce symptoms? Findings In this randomized optimization trial that included 767 adults with depression, 6 treatment components (activity scheduling, thought challenging, relaxation, concreteness training, functional analysis, and self-compassion training) did not show a significant main effect on depression.

Highlights • What is already known • Per-protocol (PP) analysis is restricted to trial participants who fulfil trial protocol adherence in terms of eligibility, interventions, and outcome assessment.

ABSTRACT FROM: Hetrick SE, Cox GR, Witt KG, et al. Cognitive–behavioural therapy (CBT), third-wave CBT and interpersonal therapy (IPT) based interventions for preventing depression in children and adolescents. Cochrane Database Syst Rev 2016;(8):CD003380. Major depressive disorder is a leading global cause of lifelong disability, with the greatest increase in incidence occurring in mid-to-late adolescence into young adulthood.