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Articles by Edward Wickstead
Roles of autophagy in brain homeostasis and disease
Abstract Macroautophagy (autophagy) is a lysosome-dependent degradative pathway that encapsulates proteins and organelles within double-membraned vesicles and recycles the contents back into the cell. The interplay of autophagy with various membrane trafficking pathways is crucial for maintaining cellular homeostasis both under basal conditions and in response to environmental stress.
Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity
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Using Stems to Bear Fruit: Deciphering the Role of Alzheimer’s Disease Risk Loci in Human-Induced Pluripotent Stem Cell-Derived Microglia
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Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class
Abstract : Formyl peptide receptors, abbreviated as FPRs in humans, are G-protein coupled receptors (GPCRs) mainly found in mammalian leukocytes. However, they are also expressed in cell types crucial for homeostatic brain regulation, including microglia and blood–brain barrier endothelial cells.
Blog | British Pharmacological Society
Published: 14 Jan 2019 Category: Equality, diversity and inclusion By Edward Wickstead The idea that mental health issues are increasingly common amongst university students compared to the general public has gained traction in recent years. For example, in 2017 the All Party Parliamentary Group of Students found that 69% of students have felt depressed within an academic year – a percentage almost three times higher than that reported for the elderly.
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