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Edwige Voisset on Muck Rack

Edwige Voisset

As seen in: Nature
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From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia - Nature Communications

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By Guillaume Andrieu, Emma Davison, Philippe Roche, Patrice Dubreuil, Sébastien Combes, Magali Saez-Ayala, Laurent Hoffer, Paul Brémond, Etienne Rebuffet, Edwige Voisset, Camille Montersino, Yves Collette, Stéphane Betzi
| Nature Verified
Abstract Cancer cells utilize the main de novo pathway and the alternative salvage pathway for deoxyribonucleotide biosynthesis to achieve adequate nucleotide pools. Deoxycytidine kinase is the rate-limiting enzyme of the salvage pathway and it has recently emerged as a target for anti-proliferative therapies for cancers where it is essential.
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