Edwin Cuppen on Muck Rack

Edwin Cuppen

Bilthoven
As seen in: Nature, Genome Medicine
Edwin Cuppen is scientific director of the Hartwig Medical Foundation a nonprofit organisation that aims to improve cancer care by whole genome sequencing
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Articles

Author Correction: Real-world clinical utility of tumor whole-genome sequencing in solid cancers

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By Jeffrey van Putten, Petur Snaebjornsson, Linda J. W. Bosch, Roelof Koster, Paul Roepman, Joseph Usset, Mirjam C. Boelens, Tom van Wezel, Efraim H Rosenberg, Serena Marchetti, Marieke Vollebergh, Doenja M. J. Lambregts, Lizet E. van der Kolk, Edwin Cuppen, Hilde H. Nienhuis, Kim Monkhorst
| Nature Verified
Correction to: Nature Medicine https://doi.org/10.1038/s41591-026-04280-2, published online 20 March 2026. In the version of this article initially published, due to a version error, values listed on the right-hand side of Fig.
Open in Who Shared Issue with article?

Real-world clinical utility of tumor whole-genome sequencing in solid cancers

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By Petur Snaebjornsson, Roelof Koster, Paul Roepman, Joseph Usset, Mirjam C. Boelens, Tom van Wezel, Efraim H Rosenberg, Serena Marchetti, Marieke Vollebergh, Edwin Cuppen, Kim Monkhorst, Jeffrey van Putten, Linda J. W. Bosch, Doenja M. J. Lambregts, Lizet E. van der Kolk, Hilde H. Nienhuis
| Nature Verified
Abstract Molecular testing is essential in precision oncology. Whole-genome sequencing (WGS) provides a tumor-agnostic solution for detecting an increasingly complex range of DNA-based biomarkers. Here we present real-world data from 888 patients to demonstrate the clinical utility of routine, paired tumor-normal WGS diagnostics for solid cancers in a comprehensive cancer center. WGS succeeded in 89% of cases with a median turnaround time of 6 working days.
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Clinical implications of whole genome sequencing in metastatic colorectal cancer - Oncogene

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By Lidwien P. Smabers, Onno Kranenburg, Miriam Koopman, Edwin Cuppen
| Nature Verified
Abstract Whole genome sequencing (WGS) provides complete genetic information in one test, supporting the shift towards individualized metastatic colorectal cancer (mCRC) treatment. Although WGS is validated as a diagnostic test, the potential clinical implications for mCRC remain unknown. We evaluated the clinical consequences of WGS in 96 mCRC patients.
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