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Articles by Edwin Escobar
Semirandom DNA adducts regulate a filamentous defense-associated reverse transcriptase
Abstract Retrons and several defense-associated reverse transcriptases (DRTs) synthesize non-genomic DNA for bacteriophage immunity. In some instances, this non-genomic DNA is of undefined, semirandom sequence. How undefined DNA sequences impart antiphage defense is not known. Herewe report the cryo-EM structure and functional characterization of the DRT1 antiphage defense system. We show that DRT1 performs template-free, protein-primed DNA synthesis to generate semirandom DNA adducts.
A tunable CTD grammar governs the spatial programming of the transcription cycle
Abstract RNA polymerase II transcribes all protein-coding genes in eukaryotes, with its C-terminal domain (CTD) acting as a regulatory platform throughout the transcription cycle. Despite its simple sequence, the conserved heptad repeats encode a regulatory grammar critical for transcription initiation, elongation, and termination.
Prehospital management and postoperative course of patients with acute appendicitis treated at the Jipijapa Basic Hospital in Ecuador
Ayuda Buscar en la ayuda Buscar en la ayuda Prehospital management and postoperative course of patients with acute appendicitis treated at the Jipijapa Basic Hospital in Ecuador Escobar, Edwin [1] ; Marín, Alfredo L. [1] ; Toledo, Nancy [1] ; Macías, Cristhian S. [1] [1] Faculty of Health Sciences, Technical University of Manabí, Portoviejo, Ecuador Localización: Journal of Advances in Education, Sciences and Humanities, ISSN-e 3091-1583, Vol. 3, Nº.
Application of post glycosylation modifying enzymes for mass spectrometry imaging of modified N-glycans in situ.
Abstract Glycans are essential components of cells and are involved in innumerable biological processes. Their structural diversity and complexity present unique analytical challenges. Glycans are comprised of various types of monosaccharides that are linked together at different positions and with varied stereochemistry. In addition, glycans are frequently decorated with a diverse set of chemical modifications, termed post-glycosylation modifications (PGMs).
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In Situ Imaging of O-Linked β-N-Acetylglucosamine Using On-Tissue Hydrolysis and MALDI Mass Spectrometry
Abstract : Simple Summary Post-translational O-glycosylation of proteins with N-acetylglucosamine serves as a cellular regulator that has been linked to cancer. This sugar’s variability is emerging as a metabolic biomarker in cancer, and here we investigate the use of mass spectrometry imaging to visualize the location of this sugar in primary tumor sections.
Evaluating Spatiotemporal Dynamics of Phosphorylation of RNA Polymerase II Carboxy-Terminal Domain by Ultraviolet Photodissociation Mass Spectrometry
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2021, XXXX, XXX Edwin E. Escobar Edwin E. Escobar Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States , Mukesh Kumar Venkat Ramani Mukesh Kumar Venkat Ramani Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas 78712, United States , Yan Zhang, and Jennifer S.
Precision Mapping of O-Linked N-Acetylglucosamine Sites in Proteins Using Ultraviolet Photodissociation Mass Spectrometry
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2020, XXXX, XXX RETURN TO ARTICLES ASAPPREVArticleNEXT Edwin E. Escobar Edwin E. Escobar Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States , Dustin T. King Dustin T. King Department of Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada , Jesús E. Serrano-Negrón Jesús E.
FAMU Army ROTC travels to Vietnam - The Westside Gazette
This year, the Florida A&M University Army ROTC had the honor of becoming a partner in the United States of America Vietnam War Commemoration, which also coincides with the Secretary of Defense’s commemoration of the 50th anniversary of the Vietnam War.
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