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Edwin Escobar on Muck Rack

Edwin Escobar

As seen in: Nature, MDPI, ACS Publications, BioRxiv, Dialnet - Universidad de La Rioja, The Westside Gazette
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Articles

Semirandom DNA adducts regulate a filamentous defense-associated reverse transcriptase

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By Nolan Neville, Nicole Johnson, Edwin Escobar, Chang-Hwa Chiang, Sean Johnson, Nan Dai, Jason S. McLellan, Robert J. Iii, Albana Nreca, Andy Hanneman, Ivan R. Corrêa Jr
| Nature Verified
Abstract Retrons and several defense-associated reverse transcriptases (DRTs) synthesize non-genomic DNA for bacteriophage immunity. In some instances, this non-genomic DNA is of undefined, semirandom sequence. How undefined DNA sequences impart antiphage defense is not known. Herewe report the cryo-EM structure and functional characterization of the DRT1 antiphage defense system. We show that DRT1 performs template-free, protein-primed DNA synthesis to generate semirandom DNA adducts.
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A tunable CTD grammar governs the spatial programming of the transcription cycle

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By Qian Zhang, Haley A. Hardtke, Yuanmin Zheng, Alan Gerber, Edwin Escobar, Jennifer S. Brodbelt, Ruobo Zhou, Y. Zhang
| Nature Verified
Abstract RNA polymerase II transcribes all protein-coding genes in eukaryotes, with its C-terminal domain (CTD) acting as a regulatory platform throughout the transcription cycle. Despite its simple sequence, the conserved heptad repeats encode a regulatory grammar critical for transcription initiation, elongation, and termination.
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Prehospital management and postoperative course of patients with acute appendicitis treated at the Jipijapa Basic Hospital in Ecuador

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By Edwin Escobar, nancy santana, Alfredo L. Marín, Cristhian S. Macías
| Dialnet - Universidad de La Rioja
Ayuda Buscar en la ayuda Buscar en la ayuda Prehospital management and postoperative course of patients with acute appendicitis treated at the Jipijapa Basic Hospital in Ecuador Escobar, Edwin [1] ; Marín, Alfredo L. [1] ; Toledo, Nancy [1] ; Macías, Cristhian S. [1] [1] Faculty of Health Sciences, Technical University of Manabí, Portoviejo, Ecuador Localización: Journal of Advances in Education, Sciences and Humanities, ISSN-e 3091-1583, Vol. 3, Nº.
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