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IL-36R signaling integrates innate and adaptive immune-mediated protection against enteropathogenic bacteria Vu L. Ngo, Hirohito Abo, Michal Kuczma, Edyta Szurek, Nora Moore, Oscar Medina-Contreras, Asma Nusrat, Didier Merlin, Andrew T. Gewirtz, Leszek Ignatowicz, Timothy L. Denning Proceedings of the National Academy of Sciences Oct 2020, 202004484; DOI: 10.1073/pnas.2004484117
Abstract The gut microbiome is the largest source of intrinsic non–self-antigens that are continuously sensed by the immune system but typically do not elicit lymphocyte responses. CD4+ T cells are critical to sustain uninterrupted tolerance to microbial antigens and to prevent intestinal inflammation. However, clinical interventions targeting commensal bacteria–specific CD4+ T cells are rare, because only a very limited number of commensal-derived epitopes have been identified.
Loading metrics Open Access Peer-reviewed Research Article Binnur Eroglu, Edyta A. Szurek, Peter Schall, Keith E. Latham , Ali Eroglu Binnur Eroglu, Edyta A. Szurek, Peter Schall, Keith E.
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