Egambaram Premkumar

Synthesis of lactones and lactams via C(sp3)–H bond functionalization The field of directing group-assisted, transition-metal-catalyzed functionalization has undergone a significant transformation, evolving from the use of auxiliary group attachment for the exploitation of native functional groups in novel organic reactions. In particular, coordination-assisted C(sp3)–H bond functionalization has revolutionized synthetic planning to build molecular complexity.

An Expedient Ruthenium(II) Catalyzed Multicomponent Access to Phthalazinones Bearing Trisubstituted Alkenes Nitrogen based heterocycles bearing trisubstituted alkenes are prodigious and indispensable motifs in pharmaceuticals, clinical candidates and functional materials. Herein, we developed tandem one-pot ruthenium-catalyzed multicomponent reaction to access phthalazinones bearing trisubstituted alkenes by employing readily available hydrazines, 2-formyl-benzoic acid and alkynes.

Herein, we report an oxygen insertion in activated ketones from simple inorganic carbonates for the synthesis of symmetric aromatic anhydrides. For the first time, Li2CO3 acts as an oxygen source and the in situ generated symmetric aromatic anhydrides undergo Pummerer-type rearrangement to access α-benzoyloxy–thioethers. Attractively, this protocol occurs under metal-, ligand-, and oxidant-free conditions and is compatible with a wide range of substrates.