Egan Choi

Also available on ScienceDirect

1. Introduction Neurointestinal diseases comprise a range of medical conditions that result from the interplay and malfunctioning of the nervous system and the GI system [1]. These disorders are characterized by aberrations in the communication among the brain, the enteric nervous system (ENS)—an intricate network of neurons within the GI tract frequently referred to second brain in the gut—and the gut [2].

Abstract : Due to modern medical advancements, greater proportions of the population will continue to age with longer life spans. Increased life span, however, does not always correlate with improved health span, and may result in an increase in aging-related diseases and disorders. These diseases are often attributed to cellular senescence, in which cells become disengaged from the cell cycle and inert to cell death. These cells are characterized by a proinflammatory secretome.