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Ehab M. Moussa on Muck Rack

Ehab M. Moussa

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Articles

Chemistry, manufacturing and controls strategies for using novel excipients in lipid nanoparticles - Nature Nanotechnology

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By David Foley, Jacob Lewis, Eric L. Dane, Olivier Dirat, Ehab M. Moussa, Matthew O’Brien Laramy, Roger H. Pak
| Nature Verified
Abstract Lipid nanoparticles (LNPs) for nucleic acid delivery often use novel lipids as functional excipients to modulate the biodistribution, pharmacokinetics, pharmacodynamics and efficacy of the nucleic acid. Novel excipients used in pharmaceutical products are subject to heightened regulatory scrutiny and often require data packages comparable to an active pharmaceutical ingredient.
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Probing the Conformation of an IgG1 Monoclonal Antibody in Lyophilized Solids Using Solid-State Hydrogen-Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS) - Molecular Pharmaceutics (ACS Publications)

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By Satish Singh, Michael Kimmel, Ehab M. Moussa, Sandeep Nema
| American Chemical Society
Therapeutic proteins are often formulated as lyophilized products to improve their stability and prolong shelf life. The stability of proteins in the solid-state has been correlated with preservation of native higher order structure and/or molecular mobility in the solid matrix, with varying success.
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