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Loss of symmetric cell division of apical neural progenitors drives DENND5A-related developmental and epileptic encephalopathy - Nature Communications
Abstract Developmental and epileptic encephalopathies (DEEs) feature altered brain development, developmental delay and seizures, with seizures exacerbating developmental delay. Here we identify a cohort with biallelic variants in DENND5A, encoding a membrane trafficking protein, and develop animal models with phenotypes like the human syndrome.
What’s in a Love Potion?
She said “I’m gonna make it up right here in the sink” It smelled like turpentine and looked like India ink. The song “Love Potion No. 9” was a hit for The Clovers in 1959 and then again for The Searchers in 1965. But the ingredients of the titular potion were left a little vague in Jerry Leiber and Mike Stoller’s lyrics. It is, after all, supposed to be a magic potion, and the key to magic is secret knowledge, the possession of the witch, available for a price— maybe a soul.
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