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Eilley W. Barron on Muck Rack

Eilley W. Barron

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Articles

Targeting microtubule dynamics with mebendazole slows disease progression in ADPKD mice

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By Qin Yao, Terry Watnick, Valeriu Cebotaru, Eilley W. Barron, Patricia Outeda
| Nature Verified
Abstract Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder and is primarily caused by mutations in PKD1 or PKD2. The disease is characterized by the progressive development and enlargement of fluid-filled renal cysts over decades. Microtubules (MTs) are highly dynamic cytoskeletal structures that continuously alternate between growth and shortening to support a wide range of cellular processes, including cell proliferation.
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