Einollah Sarikhani

1 Introduction Mechanotransduction, the set of processes by which cells respond to mechanical cues by altering their signaling response, is critical for integration of chemical and physical stimuli in different physiological environments.

Abstract Nuclear translocation of the transcription regulatory proteins YAP and TAZ is a critical readout of cellular mechanotransduction. Recent experiments have demonstrated that cells on substrates with well-defined nanotopographies demonstrate mechanoadaptation through a multitude of effects - increased integrin endocytosis as a function of nanopillar curvature, increased local actin assembly on nanopillars but decreased global cytoskeletal stiffness, and enhanced nuclear deformation.

Zeinab Jahed Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, San Diego, CA, 92093 USA Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, San Diego, CA, 92093 USA Search for more papers by this author