Eisa Mohamed Hegazy

1 Introduction Melasma is a common acquired hyperpigmentary condition characterized by chronic, relapsing, symmetrical brown to gray-brown macules and patches primarily involving sun-exposed areas of the face. It is frequent in Fitzpatrick skin types III-V and commonly affects centrofacial, malar, and mandibular regions.

1 INTRODUCTION Psoriasis refers to a persistent inflammatory illness of the skin and joints. It also impacts roughly 2%–3% of the inhabitants of the universe.1 Psoriasis pathophysiology is still poorly understood. Several proinflammatory cytokines and cytokine receptors have been implicated in its pathophysiology.2 TWEAK is a transmembrane protein that is found in different subsets of skin cells and is included in a various physiologic and pathological procedures.

Mahmoud Ahmed Ali,1 Moustafa Adam El Taieb,1 Eisa Mohamed Hegazy,2 Hassan M Ibrahim,2 Alshimaa Abbas Mohamed,1 Mohamed Amer Ahmed Abdellatif,1 Nour Mohammed Ahmed,3 Ali Mohamed Younis1 1Dermatology, Venereology, and Andrology Department, Faculty of Medicine, Aswan University, Aswan, Egypt; 2Dermatology, Venereology, and Andrology Department, Faculty of Medicine South Valley University, Qena, Egypt; 3Clinical Pathology Department, Faculty of Medicine, Aswan University, Aswan, Egypt...