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Elaina N. Barela on Muck Rack

Elaina N. Barela

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Articles

Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of estrogen receptor-positive breast cancer brain metastases

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By Morgan Fox, Jenny A. Jaramillo-Gómez, R. Alejandro Marquez-Ortiz, Maria J Contreras-Zarate, Trinh Pham, Peter Kabos, Natalie J. Serkova, Carol A Sartorius, Elizabeth A. Wellberg, Diana M. Cittelly, Karen L. F. Alvarez-Eraso, Elaina N. Barela, Stella N. Koliavas
| Nature Verified
Abstract Estrogen receptor-positive breast cancer represents a significant proportion of breast cancer brain metastasis but remains understudied. Here we show that FGFR1-amplification, a well-established driver of estrogen receptor-positive breast cancer endocrine resistance, promotes estrogen receptor-positive breast cancer brain metastatic colonization in young and aged female mice, through both canonical FGF2/FGFR1 signaling and non-canonical NCAM1/FGFR1 interactions.
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