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Elena Anne Seiß on Muck Rack

Elena Anne Seiß

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Articles

Glucocorticoids attenuate interleukin‐6‐induced c‐Fos and Egr1 expression and impair neuritogenesis in PC12 cells

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By Hannes Bongartz, Elena Anne Seiß, Jörg Bock, Fred Schaper
| Wiley Online Library Verified
Abstract Interleukin‐6 (IL‐6) is a cytokine primarily known for immune regulation. There is also growing evidence that IL‐6 triggers neurogenesis and impacts neural development, both life‐long occurring processes that can be impaired by early‐life and adult stress. Stress induces the release of glucocorticoids by activation of the hypothalamic–pituitary–adrenal (HPA) axis. On the cellular level, glucocorticoids act via the ubiquitously expressed glucocorticoid receptor.
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