Elena Maria Varoni

Syphilis, caused by the spirochete Treponema pallidum, is a sexually transmitted infection (STI), also transmissible vertically.1,2 Global incidence has risen sharply,3 with 8 million new cases and 700 000 congenital infections in 2022,4 highlighting its public health impact. Oral manifestations, most common in secondary syphilis, can occasionally be the sole symptom.

1 CASE REPORT A 59-year-old man came to the emergency room of our department for the presence of a gingival mass that has lasted for 4 months. In his clinical history, the patient reported being affected by HIV since 1985 (currently treated with association of doravirine and abacavir/lamivudine); no further diseases were referred. No pain was reported by the patient and, at the clinical examination, no cervical lymphadenopathy or submandibular mass were observed.

REVIEW Mehdi Sharifi-Rad, Mehdi Sharifi-Rad orcid.org/0000-0001-8213-9097 Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol, 61663-335 Iran Mehdi Sharifi-Rad and Elena Maria Varoni are co-first authors. Search for more papers by this author Elena Maria Varoni, Elena Maria Varoni orcid.org/0000-0002-7287-2188 Department of Biomedical, Surgical and Dental Sciences, Milan State University, Milan, Italy Mehdi Sharifi-Rad and Elena Maria Varoni are co-first authors.