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Elena Rebollo-Gomez on Muck Rack

Elena Rebollo-Gomez

As seen in: BioRxiv
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Articles

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development

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By Benoit Bilanges, Christina JF Courreges, Elizabeth CM Davenport, Elena Rebollo-Gomez
| BioRxiv
Abstract Regulatory T (Treg) cells are essential for the maintenance of immunological tolerance, yet the molecular components required for their maintenance and effector functions remain incompletely defined. Inactivation of VPS34 in Treg cells led to an early, lethal phenotype, with massive effector T cell activation and inflammation, like mice lacking Treg cells completely.
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