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Highlights • Neutrophils have variable lifetimes in tissues • Neutrophils acquire distinct phenotypic and functional properties in tissues • Tissue-derived signals drive rapid adaptation of neutrophils • Neutrophil reprogramming in the lungs occurs in CXCL12+ niches. Summary Classically considered short-lived and purely defensive leukocytes, neutrophils are unique in their fast and moldable response to stimulation.
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