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Elham Ben Saad on Muck Rack

Elham Ben Saad

As seen in: BioRxiv
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Articles

PD-1 endocytosis unleashes the cytolytic potential of check-point blockade in tumor immunity

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By Elham Ben Saad, Andres Oroya, Nikhil Ponnoor Anto, Meriem Bachais
| BioRxiv
Abstract PD-1 immune checkpoint blockade (ICB) is now a promising first-line treatment for many cancers. While the steric blockade of PD-1 binding to its ligand plays a role, the role of internalisation in promoting the efficacy of ICB has not been explored. In this study, we show that PD-1 internalisation also contributes by unlocking the full cytolytic potential of ICB in cancer immunotherapy.
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