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Articles by Eli Muller
Thalamic modulation of cortical linearity across arousal states
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract The human brain must support both stable and flexible neural dynamics to adapt to changing contexts.
Modeling the influences of non-local connectomic projections on geometrically constrained cortical dynamics
Citation: Maran R, Müller EJ, Fulcher BD (2026) Modeling the influences of non-local connectomic projections on geometrically constrained cortical dynamics. PLoS Comput Biol 22(8): e1014673. https://doi.org/10.1371/journal.pcbi.1014673 Editor: Thomas Serre, Brown University, UNITED STATES OF AMERICA Received: March 20, 2026; Accepted: August 5, 2026; Published: August 26, 2026 Copyright: © 2026 Maran et al.
Cerebellar and subcortical contributions to working memory manipulation - Communications Biology
Abstract Working memory is critical for manipulating and temporarily storing information during cognitive tasks such as problem-solving. Most models focus primarily on cortical-cortical interactions, neglecting subcortical and cerebellar contributions. Given the extensive connectivity between the cerebellum, subcortex, and cortex, we hypothesize that they contribute distinct, yet complementary, functions during working memory manipulation.
Human thalamocortical structural connectivity develops in line with a hierarchical axis of cortical plasticity - Nature Neuroscience
Abstract Human cortical development follows a hierarchical, sensorimotor-to-association sequence. The brain’s capacity to enact this sequence indicates that it relies on unknown mechanisms to regulate regional differences in the timing of cortical maturation.
Brain-Wide Impacts of Sedation on Spontaneous Activity and Auditory Processing in Larval Zebrafish
Brain-Wide Impacts of Sedation on Spontaneous Activity and Auditory Processing in Larval Zebrafish Itia A. Favre-Bulle, Eli Muller, Conrad Lee, Leandro A. Scholz, Joshua Arnold, Brandon Munn, Gabriel Wainstein, James M. Shine, Ethan K. Scott Journal of Neuroscience 9 April 2025, 45 (15) e0204242025; DOI: 10.1523/JNEUROSCI.0204-24.2025
A burst-dependent thalamocortical substrate for perceptual awareness
Citation: Whyte CJ, Müller EJ, Aru J, Larkum M, John Y, Munn BR, et al. (2025) A burst-dependent thalamocortical substrate for perceptual awareness. PLoS Comput Biol 21(4): e1012951. https://doi.org/10.1371/journal.pcbi.1012951 Editor: Boris S. Gutkin, École Normale Supérieure, College de France, CNRS, FRANCE Received: July 25, 2024; Accepted: March 11, 2025; Published: April 7, 2025 Copyright: © 2025 Whyte et al.
Thalamic Influence Over Adaptive Cortical Dynamics Across Conscious States
Abstract The human brain must support both stable and flexible neural dynamics in order to adapt to changing contexts that are inherently non-linear. The thalamus has been linked to the coordination of these opposing dynamical regimens in the cerebral cortex, however existing methodological approaches have not integrated sufficient neurobiological details with a sensitive measure of neural dynamics that permits sensitivity to time-series non-linearities.
Brain-wide impacts of sedation on spontaneous activity and auditory processing in larval zebrafish
Abstract Despite their widespread use, we have limited knowledge of the mechanisms by which sedatives mediate their effects on brain-wide networks. This is, in part, due to the technical challenge of observing activity across large populations of neurons in normal and sedated brains.
A Burst-dependent Thalamocortical Substrate for Perceptual Awareness
Abstract Contemporary models of perceptual awareness lack tractable neurobiological constraints. Inspired by recent cellular recordings in a mouse model of tactile threshold detection, we constructed a biophysical model of perceptual awareness that incorporated essential features of thalamocortical anatomy and cellular physiology.
Thalamic Control Over Laminar Cortical Dynamics Across Conscious States
Abstract The human brain must support both stable and flexible neural dynamics in order to adapt to changing contexts. This paper investigates the role of the thalamus, a crucial subcortical structure, in orchestrating these opposing dynamics in the cerebral cortex. Through two distinct classes of cortical projections, the thalamus is able to support distinct dynamics modes: some cells relay precise information between cortical regions, whereas others diffusely modulate ongoing cortical dynamics.
Phylogenetically-Preserved Multiscale Neuronal Activity: Iterative Coarse-Graining Reconciles Scale-Dependent Theories of Brain Function
Abstract Brain recordings collected at different resolutions support statistically distinct signatures of information processing, leading to scale-dependent theories of brain function. Here, we demonstrate that these disparate neural-coding signatures emerge from the same multiscale functional organisation of neuronal activity across calcium-imaging recordings collected from the whole brains of zebrafish and nematode, as well as sensory regions of the fly, mouse, and macaque brain.
Personalized stimulation therapies for disorders of consciousness: A computational approach to inducing healthy-like brain activity based on neural field theory
Abstract Disorders of consciousness (DoC) pose significant challenges in neurology. Conventional neuromodulation therapies for DoC have exhibited limited success, with varying effectiveness among patients. In this study, we introduce a computational approach for constructing personalized stimulus signals capable of inducing healthy-like neural activity patterns in DoC patients.
Brain-wide impacts of sedation on spontaneous activity and auditory processing in larval zebrafish
Abstract Despite their widespread use, we have limited knowledge of the mechanisms by which sedatives mediate their effects on brain-wide networks. This is, in part, due to the technical challenge of observing activity across large populations of neurons in normal and sedated brains. In this study, we examined the effects of the sedative dexmedetomidine, and its antagonist atipamezole, on spontaneous brain dynamics and auditory processing in zebrafish larvae.
Criticality supports cross-frequency cortical-thalamic information transfer during conscious states
Data availability The source data underlying Figures 2-5 and 8-9, and code necessary to run the mean-field simulations of waking, seizure, and anesthesi states are available at https://doi.org/10.6084/m9.figshare.24777081.v2. The raw electrophysiology recordings from Long-Evans rats are available at the Harvard Dataverse Network, with the following DOI: doi:10.7910/DVN/29366.
Neuronal connected burst cascades bridge macroscale adaptive signatures across arousal states - Nature Communications
Abstract The human brain displays a rich repertoire of states that emerge from the microscopic interactions of cortical and subcortical neurons. Difficulties inherent within large-scale simultaneous neuronal recording limit our ability to link biophysical processes at the microscale to emergent macroscopic brain states.
Translating electrophysiological signatures of awareness into thalamocortical mechanisms by inverting systems-level computational models across arousal states
Abstract While consciousness never fades during wakefulness, there is a paradoxical coexistence of consciousness during dreaming states. It is also possible for sensory awareness to be either present or absent when awakened from seemingly-identical states of sedation and anaesthesia. Traditionally, these states have been characterised by their electroencephalographic neural correlates, however, without clear underlying neurobiological mechanisms.
The non-specific matrix thalamus facilitates the cortical information processing modes relevant for conscious awareness
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Criticality supports cross-frequency cortical-thalamic information transfer during conscious states
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Author Correction: Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics
Correction to: Nature Neuroscience https://doi.org/10.1038/s41593-021-00824-6, published online 6 May 2021. In the version of this article initially published, the image credit for Fig. 3f was omitted, and the related reference (van den Brink, Pfeffer & Donner, 2019) was missing. The errors have been corrected in the PDF and HTML versions of this article. Author information Author notes These authors contributed equally: James M. Shine, Eli J. Müller.
Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics - Nature Neuroscience
Abstract Decades of neurobiological research have disclosed the diverse manners in which the response properties of neurons are dynamically modulated to support adaptive cognitive functions. This neuromodulation is achieved through alterations in the biophysical properties of the neuron. However, changes in cognitive function do not arise directly from the modulation of individual neurons, but are mediated by population dynamics in mesoscopic neural ensembles.
Diffuse neural coupling mediates complex network dynamics through the formation of quasi-critical brain states
Abstract The biological mechanisms that allow the brain to balance flexibility and integration remain poorly understood. A potential solution may lie in a unique aspect of neurobiology, which is that numerous brain systems contain diffuse synaptic connectivity.
Porn ‘N Chicken headed to the tube
It’s nothing special, just your run of the mill case of art imitating life. Or rather, life imitating pornography, art imitating life and pornography imitating art. Nearly a year ago, members of a Yale group called Porn ‘N Chicken announced their plan to produce Yale’s first pornography flick, prompting months of premature media ejaculations.
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