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Eliceo Cortés

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Articles

In silico discovery of thioglycoside analogues as donor-site inhibitors of glycosyltransferase LgtC

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By Olimpo Sierra-Hernandez, Oscar Saurith-Coronell, Jackson J. Alcázar, Máryury Flores-Sumoza, José Mora, Yovani Marrero-Ponce, Ernesto Contreras-Torres, Eliceo Cortés, Juan D. Rodríguez-Macías, Edgar A. Márquez Brazón
| Nature Verified
Abstract The growing prevalence of multidrug-resistant Gram-negative pathogens highlights the urgent need for therapeutic strategies that complement traditional antibiotics by targeting essential virulence pathways. Glycosyltransferase LgtC, a key enzyme in lipooligosaccharide (LOS) biosynthesis, represents an attractive target for antivirulence approaches because of its essential role in bacterial immune evasion and pathogenicity.
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