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Abstract This prospective interventional case study aimed to describe the anatomical and functional outcomes of pars plana vitrectomy (PPV) with adjunct highly concentrated autologous platelet-rich plasma (PRP) in patients with symptomatic, progressive lamellar macular hole (LMH) over an extended follow-up period. 20 eyes of 20 patients were included with a minimum follow-up of 24 months (mean 40.2 ± 11.8 months) and a morphological diagnosis of LMH.
2.1. Morphological Findings Preoperatively, all patients fulfilled the mandatory criteria for LMH on SD-OCT. Next to the irregular foveal contour, the foveal cavity with undermined edges and signs of foveal tissue loss, and associated alterations on SD-OCT, were present at the vitreoretinal interface, as shown in Table 1.
Abstract The variable clinical course of follicular lymphoma (FL) is determined by the molecular heterogeneity of tumor cells and complex interactions within the tumor microenvironment (TME). IL-4 producing follicular helper T cells (TFH) are critical components of the FL TME. Binding of IL-4 to IL-4R on FL cells activates JAK/STAT signaling. We identified STAT6 mutations (STAT6MUT) in 13% of FL (N = 33/258), all clustered within the DNA binding domain.
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