Elita Peters

G4s Assemble Cation-Stabilized DNA Membrane Receptors Our DNA nanodevices consist of 56 base-pair (bp) long duplexes composed of four synthetic DNA oligonucleotides ( Tables S1 and S2 ), featuring a terminal overhang with six consecutive guanines, (G) 6 , that allow for receptor assembly via an intermolecular G-quadruplex.

Journal of the American Chemical Society Cite this: J. Am. Chem. Soc. 2025, XXXX, XXX Click to copy citationCitation copied! . This publication is licensed under CC-BY 4.0 . You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters below: Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator.

Abstract Biological cells use cations as signalling messengers to regulate a variety of responses. Linking cations to the functionality of synthetic membranes is thus crucial to engineering advanced biomimetic agents, such as synthetic cells. Here, we introduce bio-inspired DNA-based receptors that exploit non-canonical G-quadruplexes for cation-actuated structural and functional responses in synthetic lipid membranes.