Elitsa A. Ananieva on Muck Rack

Elitsa A. Ananieva

As seen in: Nature
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Articles

Blocking mitochondrial leucine transamination enhances T-cell activation and improves T-cell immunity against OVA-producing EL4 lymphoma

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By Emily Baer, Alexander Martin, Michael Boyer, Elitsa A. Ananieva, Christie M. Adam, Tanner J. Wetzel, Sheila C. Erfan, Leighton M. Wheeler, Lindsey P. Croll, Max L. Swain
| Nature Verified
Abstract T-cell metabolism is targeted by cancer cells in an attempt to escape immune surveillance. The mitochondrial branched-chain aminotransferase, BCATm, is overexpressed in cancer, yet its role in T-cell immunity is suggested but understudied. C57BL/6 mice with T-cell specific-single BCATm deficiency were used to determine the impact of BCATm on T-cell function in vitro and in vivo using the murine EL4-OVA lymphoma.
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Mice deficient in the mitochondrial branched-chain aminotransferase (BCATm) respond with delayed tumour growth to a challenge with EL-4 lymphoma

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By Joshua N Bostic, Ashley Torres, Elitsa A. Ananieva, Hannah R. Glanz
| Nature Verified
The mitochondrial branched-chain aminotransferase (BCATm) is a recently discovered cancer marker with a poorly defined role in tumour progression. To understand how a loss of function of BCATm affects cancer, the global knockout mouse BCATmKO was challenged with EL-4 lymphoma under different diet compositions with varying amounts of branched-chain amino acids (BCAAs).
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