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Articles by Elizabeth Jonas
Employer Considerations After 11th Circ. Gender Care Ruling
By Joanne Roskey and Elizabeth Jonas ( November 10, 2025, 5:22 PM EST) -- On Sept. 9, the U.S. Court of Appeals for the Eleventh Circuit, sitting en banc in Lange v. Houston County, Georgia, found that a county health plan did not facially violate Title VII of the Civil Rights Act on the basis of sex when it covered medically necessary treatments for certain diagnoses, but excluded coverage for gender-affirming care sought by the plaintiff.... Law360 is on it, so you are, too.
Insights On 11th Circ. Panel's Approach In Gender Care Case
By Joanne Roskey and Elizabeth Jonas ( November 10, 2025, 5:22 PM EST) -- On Sept. 9, the U.S. Court of Appeals for the Eleventh Circuit, sitting en banc in Lange v. Houston County, Georgia, found that a county health plan did not facially violate Title VII of the Civil Rights Act on the basis of sex when it covered medically necessary treatments for certain diagnoses, but excluded coverage for gender-affirming care sought by the plaintiff.... Law360 is on it, so you are, too.
Full 11th Circ. Gender Care Ruling Highlights State Law Risks
By Joanne Roskey and Elizabeth Jonas ( November 10, 2025, 5:22 PM EST) -- On Sept. 9, the U.S. Court of Appeals for the Eleventh Circuit, sitting en banc in Lange v. Houston County, Georgia, found that a county health plan did not facially violate Title VII of the Civil Rights Act on the basis of sex when it covered medically necessary treatments for certain diagnoses, but excluded coverage for gender-affirming care sought by the plaintiff.... Law360 is on it, so you are, too.
Full 11th Circ. Gender Care Ruling Highlights State Law Risks
By Joanne Roskey and Elizabeth Jonas ( November 10, 2025, 5:22 PM EST) -- On Sept. 9, the U.S. Court of Appeals for the Eleventh Circuit, sitting en banc in Lange v. Houston County, Georgia, found that a county health plan did not facially violate Title VII of the Civil Rights Act on the basis of sex when it covered medically necessary treatments for certain diagnoses, but excluded coverage for gender-affirming care sought by the plaintiff....
Employer Considerations After 11th Circ. Gender Care Ruling
By Joanne Roskey and Elizabeth Jonas ( November 10, 2025, 5:22 PM EST) -- On Sept. 9, the U.S. Court of Appeals for the Eleventh Circuit, sitting en banc in Lange v. Houston County, Georgia, found that a county health plan did not facially violate Title VII of the Civil Rights Act on the basis of sex when it covered medically necessary treatments for certain diagnoses, but excluded coverage for gender-affirming care sought by the plaintiff....
Reduced DJ-1-F1Fo ATP synthase association correlates with midbrain dopaminergic neuron vulnerability in idiopathic Parkinson’s disease
Abstract Disruption in neuronal and synaptic metabolic homeostasis is a key driver of neurodegeneration in Parkinson’s disease (PD). Mitochondrial activity, biomass, and efficiency are critical to this balance. While activity and biomass are well characterized in PD pathology, mitochondrial metabolic efficiency remains insufficiently explored.
Development of a floxed Gabbr2 gene allows for widespread conditional disruption of GABBR2 and recapitulates the phenotype of germline Gabbr2 knockout mice
Abstract GABBR1 and GABBR2 are widely expressed in the brain and genetic inhibition of their function leads to widespread neurologic dysfunction and premature death in mice. Given that GABBR1 and GABBR2 heterodimerize to form a functional receptor, global knockout of GABBR1 or GABBR2 results in a similar phenotype, characterized by spontaneous epileptiform activity, hyperlocomotor activity, hyperalgesia, impaired memory and premature death.
Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions - Cell Death & Differentiation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Dog Days Of Summer Pave The Way For Continuing Rise In ERISA Litigation: Summer 2021 ERISA Litigation Update
To print this article, all you need is to be registered or login on Mondaq.com. Three important Employee Retirement Income Security Act of 1974 (ERISA) breach of fiduciary decisions came down this summer. In Sacerdote v.
ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration
Highlights • ATP synthase c-subunit is the leak channel of mitochondrial permeability transition. • c-subunit channel is the master regulator of cell metabolism in embryonic and synaptic development. • F1/FO stoichiometry change is critical for c-subunit regulatory function. • Non-reversible dissociation of ATP synthase F1 from FO triggers age-related ischemic and degenerative diseases. • We discuss models for ATP synthase channel gating in physiological and pathological conditions.
Dopamine fuels its own release
A new study shows that the enzyme monoamine oxidase funnels a byproduct of dopamine metabolism, H2O2, directly into the mitochondrial electron transport chain, stimulating ATP production. This alternative energy pathway may protect dopaminergic neurons from the toxicity induced by dopamine metabolism while supporting phasic firing. Fig. 1: Alternative bioenergetic pathway used for ATP production during dopamine metabolism. References 1. Buhmann, C. et al. Neurobiol. Dis. 15, 160–170 (2004). 2. Graves, S. M.
BDNF signaling: Harnessing stress to battle mood disorder
The link between the onset of major depressive disorder (MDD) and loss of neurotrophins in the brain is of interest to clinicians and basic scientists. MDD is caused by a combination of genetic, environmental, and psychological factors. Trauma, chronic health problems, and substance abuse are risks (1), as are grief and other purely emotional/cognitive stresses (2, 3). MDD alters the expression of neurotrophins, such as brain-derived neurotrophic factor (BDNF).
The MIFstep in parthanatos
If we knew how cells die, we might be able to prevent cell death, thereby saving vital tissues and organs in diseases as diverse as heart attack, stroke, diabetes, liver and kidney failure, and neurodegenerative diseases of the brain. Indeed, it has become clear from recent studies on anastasis, or reversal of apoptotic cell death (1), that cells can survive many severe insults and recover completely. On page 82 of this issue, Wang et al.
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